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ZNF638
Identifiers
Aliases	ZNF638, NP220, ZFML, Zfp638, zinc finger protein 638
External IDs	OMIM: 614349; MGI: 1203484; HomoloGene: 7447; GeneCards: ZNF638; OMA:ZNF638 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p13.2 Start 71,276,561 bp End 71,435,069 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C3 Start 83,844,091 bp End 83,966,532 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum cerebellar hemisphere right hemisphere of cerebellum anterior pituitary ventricular zone right uterine tube tibial nerve epithelium of colon sural nerve Top expressed in genital tubercle tail of embryo ventricular zone spermatocyte ganglionic eminence zygote granulocyte pineal gland neural layer of retina cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA binding zinc ion binding double-stranded DNA binding nucleic acid binding RNA binding Cellular component cytoplasm nuclear speck intracellular membrane-bounded organelle nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27332 18139 Ensembl ENSG00000075292 ENSMUSG00000030016 UniProt Q14966 Q61464 RefSeq (mRNA) NM_001014972 NM_001252612 NM_001252613 NM_014497 NM_001166371 NM_008717 NM_001355284 NM_001355285 NM_001355286 RefSeq (protein) NP_001014972 NP_001239541 NP_001239542 NP_055312 NP_001159843 NP_032743 NP_001342213 NP_001342214 NP_001342215 NP_001393000 NP_001393001 NP_001393002 NP_001393003 NP_001393004 NP_001393005 NP_001393006 NP_001393007 NP_001393008 NP_001393009 NP_001393010 NP_001393011 NP_001393012 NP_001393013 Location (UCSC) Chr 2: 71.28 – 71.44 Mb Chr 6: 83.84 – 83.97 Mb PubMed search
Wikidata
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Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene.

The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Interactions

ZNF638 has been shown to interact with FHL2.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000075292 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030016 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Inagaki H, Matsushima Y, Nakamura K, Ohshima M, Kadowaki T, Kitagawa Y (Jul 1996). "A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain". J Biol Chem. 271 (21): 12525–31. doi:10.1074/jbc.271.21.12525. PMID 8647861.
6. ^ "Entrez Gene: ZNF638 zinc finger protein 638".
7. Ng, Enders Kai On; Chan Kwok Keung; Wong Chi Hang; Tsui Stephen Kwok Wing; Ngai Sai Ming; Lee Simon Ming Yuen; Kotaka Masayo; Lee Cheuk Yu; Waye Mary Miu Yee; Fung Kwok Pui (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. 84 (3). United States: 556–66. doi:10.1002/jcb.10041. ISSN 0730-2312. PMID 11813260. S2CID 2842198.

Further reading

• Okumara K, Nogami M, Matsushima Y, et al. (1998). "Mapping of human DNA-binding nuclear protein (NP220) to chromosome band 2p13.1-p13.2 and its relation to matrin 3". Biosci. Biotechnol. Biochem. 62 (8): 1640–2. doi:10.1271/bbb.62.1640. PMID 9757574.
• Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
• Ng EK, Chan KK, Wong CH, et al. (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. 84 (3): 556–66. doi:10.1002/jcb.10041. PMID 11813260. S2CID 2842198.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• ZNF638+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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