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POU4F2
Identifiers
Aliases	POU4F2, BRN3.2, BRN3B, Brn-3b, POU class 4 homeobox 2
External IDs	OMIM: 113725; MGI: 102524; HomoloGene: 20959; GeneCards: POU4F2; OMA:POU4F2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q31.22 Start 146,638,893 bp End 146,642,474 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Pons pancreatic ductal cell mucosa of ileum sensory ganglion trigeminal ganglion ventral tegmental area Medulla Oblongata pars compacta superior vestibular nucleus Top expressed in lumbar spinal ganglion trigeminal ganglion superior colliculus morula otolith organ inferior colliculi utricle ganglion cell layer embryo pontine nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific transcription coactivator activity transcription corepressor activity promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific p53 binding Cellular component nucleoplasm nucleus nuclear speck cytoplasm plasma membrane membrane transcription regulator complex Biological process regulation of transcription, DNA-templated axonogenesis neuromuscular process controlling balance hearing transcription, DNA-templated MAPK cascade axon guidance retina development in camera-type eye positive regulation of cell differentiation spermatogenesis neuron differentiation axon extension intracellular estrogen receptor signaling pathway retinal ganglion cell axon guidance regulation of signal transduction by p53 class mediator transcription by RNA polymerase II negative regulation of DNA-binding transcription factor activity positive regulation of transcription by RNA polymerase II positive regulation of programmed cell death negative regulation of cell differentiation positive regulation of osteoclast differentiation positive regulation of axon extension regulation of DNA-binding transcription factor activity cellular response to cytokine stimulus cellular response to estradiol stimulus intrinsic apoptotic signaling pathway by p53 class mediator regulation of retinal ganglion cell axon guidance negative regulation of amacrine cell differentiation dorsal root ganglion development positive regulation of transcription regulatory region DNA binding apoptotic process multicellular organism development cell differentiation negative regulation of transcription by RNA polymerase II heart development regulation of gene expression positive regulation of cardiac muscle cell apoptotic process cellular response to insulin stimulus positive regulation of glucose import cellular response to oxygen levels negative regulation of adipose tissue development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5458 18997 Ensembl ENSG00000151615 ENSMUSG00000031688 UniProt Q12837 Q63934 RefSeq (mRNA) NM_004575 NM_138944 RefSeq (protein) NP_004566 NP_620394 Location (UCSC) Chr 4: 146.64 – 146.64 Mb n/a PubMed search
Wikidata
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POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.

Function

POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.

Interactions

POU4F2 has been shown to interact with Estrogen receptor alpha.

See also

• BRN-3

References

1. ^ GRCh38: Ensembl release 89: ENSG00000151615 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Ring CJ, Latchman DS (Jun 1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Research. 21 (12): 2946. doi:10.1093/nar/21.12.2946. PMC 309696. PMID 8332509.
5. ^ "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".
6. Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology. 18 (2): 1029–41. doi:10.1128/mcb.18.2.1029. PMC 108815. PMID 9448000.

Further reading

• Xiang M, Zhou L, Macke JP, Yoshioka T, Hendry SH, Eddy RL, Shows TB, Nathans J (Jul 1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". The Journal of Neuroscience. 15 (7 Pt 1): 4762–85. doi:10.1523/JNEUROSCI.15-07-04762.1995. PMC 6577904. PMID 7623109.
• Xiang M, Zhou L, Peng YW, Eddy RL, Shows TB, Nathans J (Oct 1993). "Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells". Neuron. 11 (4): 689–701. doi:10.1016/0896-6273(93)90079-7. PMID 7691107. S2CID 33937730.
• Bhargava AK, Li Z, Weissman SM (Nov 1993). "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells". Proceedings of the National Academy of Sciences of the United States of America. 90 (21): 10260–4. Bibcode:1993PNAS...9010260B. doi:10.1073/pnas.90.21.10260. PMC 47754. PMID 8234287.
• Smith MD, Dawson SJ, Latchman DS (Jan 1997). "Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor". The Journal of Biological Chemistry. 272 (2): 1382–8. doi:10.1074/jbc.272.2.1382. PMID 8995448.
• Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology. 18 (2): 1029–41. doi:10.1128/mcb.18.2.1029. PMC 108815. PMID 9448000.
• Dennis JH, Budhram-Mahadeo V, Latchman DS (Aug 2001). "The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells". Oncogene. 20 (36): 4961–71. doi:10.1038/sj.onc.1204491. PMID 11526481.
• de Melo J, Qiu X, Du G, Cristante L, Eisenstat DD (Jun 2003). "Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina". The Journal of Comparative Neurology. 461 (2): 187–204. doi:10.1002/cne.10674. PMID 12724837. S2CID 2862453.
• Samady L, Dennis J, Budhram-Mahadeo V, Latchman DS (Mar 2004). "Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor". Cancer Biology & Therapy. 3 (3): 317–23. doi:10.4161/cbt.3.3.698. PMID 14726699.
• Irshad S, Pedley RB, Anderson J, Latchman DS, Budhram-Mahadeo V (May 2004). "The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo". The Journal of Biological Chemistry. 279 (20): 21617–27. doi:10.1074/jbc.M312506200. PMID 14970234.
• Lee SA, Ndisang D, Patel C, Dennis JH, Faulkes DJ, D'Arrigo C, Samady L, Farooqui-Kabir S, Heads RJ, Latchman DS, Budhram-Mahadeo VS (Apr 2005). "Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter". Cancer Research. 65 (8): 3072–80. doi:10.1158/0008-5472.CAN-04-2865. PMID 15833836.
• Weishaupt JH, Klöcker N, Bähr M (2005). "Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells". Journal of Molecular Neuroscience. 26 (1): 17–25. doi:10.1385/JMN:26:1:017. PMID 15968082. S2CID 528492.
• Samady L, Faulkes DJ, Budhram-Mahadeo V, Ndisang D, Potter E, Brabant G, Latchman DS (Feb 2006). "The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells". International Journal of Cancer. 118 (4): 869–78. doi:10.1002/ijc.21435. PMID 16152597. S2CID 41744212.
• Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP (Mar 2006). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiological Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
• Calissano M, Diss JK, Latchman DS (May 2007). "Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells". FEBS Letters. 581 (13): 2490–6. Bibcode:2007FEBSL.581.2490C. doi:10.1016/j.febslet.2007.04.066. PMID 17490655. S2CID 24033975.

External links

• POU4F2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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