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ZNF202
Identifiers
Aliases	ZNF202, ZKSCAN10, ZSCAN42, zinc finger protein 202
External IDs	OMIM: 603430; MGI: 1933401; HomoloGene: 68317; GeneCards: ZNF202; OMA:ZNF202 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q24.1 Start 123,723,914 bp End 123,741,675 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.1 Start 40,103,612 bp End 40,124,900 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte body of pancreas granulocyte gonad right ovary ventricular zone left ovary left uterine tube body of uterus rectum Top expressed in spermatocyte urethra female urethra male urethra tail of embryo genital tubercle ventricular zone trigeminal ganglion yolk sac spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding DNA-binding transcription factor activity metal ion binding DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus intracellular anatomical structure Biological process lipid metabolism transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7753 80902 Ensembl ENSG00000166261 ENSMUSG00000025602 UniProt O95125 n/a RefSeq (mRNA) NM_001301779 NM_001301780 NM_001301819 NM_003455 NM_030713 NM_001359464 RefSeq (protein) NP_001288708 NP_001288709 NP_001288748 NP_003446 n/a Location (UCSC) Chr 11: 123.72 – 123.74 Mb Chr 9: 40.1 – 40.12 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.

Clinical significance

Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000166261 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025602 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, et al. (September 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics. 52 (3): 358–362. doi:10.1006/geno.1998.5419. PMID 9790754.
6. "Entrez Gene: ZNF202 zinc finger protein 202".
7. Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A (September 2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis. 188 (1): 43–50. doi:10.1016/j.atherosclerosis.2005.10.014. PMID 16289551.

Further reading

• Iuchi S, Kuldell N (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. Springer Japan Co., Ltd. p. 161. ISBN 0-306-48229-0.
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, et al. (November 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–464. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
• Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, et al. (June 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–17179. doi:10.1074/jbc.M000119200. PMID 10747874.
• Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, et al. (May 2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". The Journal of Biological Chemistry. 275 (21): 15685–15690. doi:10.1074/jbc.M910152199. PMID 10748193.
• Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, et al. (April 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry. 276 (15): 12427–12433. doi:10.1074/jbc.M100218200. PMID 11279031.
• Babb R, Bowen BR (March 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–727. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (May 2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". Journal of Lipid Research. 47 (5): 944–952. doi:10.1194/jlr.M500521-JLR200. PMID 16467280.

External links

• ZNF202+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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