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TBPL1
Identifiers
Aliases	TBPL1, MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2, TATA-box binding protein like 1
External IDs	OMIM: 605521; MGI: 1339946; HomoloGene: 3577; GeneCards: TBPL1; OMA:TBPL1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q23.2 Start 133,952,170 bp End 133,990,432 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 A3 Start 22,579,778 bp End 22,607,837 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte left testis right testis sperm ganglionic eminence gonad prefrontal cortex Brodmann area 9 middle temporal gyrus Top expressed in spermatid spermatocyte seminiferous tubule medial ganglionic eminence tail of embryo superior cervical ganglion neural tube ventricular zone seminal vesicula granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase III transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity transcription factor binding Cellular component cytoplasm transcription factor TFIIA complex nucleus transcription factor TFIIIB complex transcription regulator complex transcription factor TFIID complex Biological process spermatid nucleus differentiation regulation of transcription, DNA-templated transcription by RNA polymerase II acrosome assembly dTTP biosynthetic process transcription, DNA-templated spermatogenesis DNA-templated transcription, initiation positive regulation of transcription by RNA polymerase II RNA polymerase III preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9519 237336 Ensembl ENSG00000028839 ENSMUSG00000071359 UniProt P62380 Q7Z6T9 P62340 RefSeq (mRNA) NM_004865 NM_001253676 NM_011603 RefSeq (protein) NP_001240605 NP_004856 NP_035733 Location (UCSC) Chr 6: 133.95 – 133.99 Mb Chr 10: 22.58 – 22.61 Mb PubMed search
Wikidata
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TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 gene.

Function

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.

Interactions

TBPL1 has been shown to interact with GTF2A1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000028839 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000071359 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ohbayashi T, Kishimoto T, Makino Y, Shimada M, Nakadai T, Aoki T, Kawata T, Niwa S, Tamura T (Feb 1999). "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein". Biochemical and Biophysical Research Communications. 255 (1): 137–42. doi:10.1006/bbrc.1999.0159. PMID 10082669.
6. Rabenstein MD, Zhou S, Lis JT, Tjian R (Apr 1999). "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4791–6. Bibcode:1999PNAS...96.4791R. doi:10.1073/pnas.96.9.4791. PMC 21770. PMID 10220372.
7. Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE (Apr 2005). "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP". Molecular and Cellular Biology. 25 (7): 2632–43. doi:10.1128/MCB.25.7.2632-2643.2005. PMC 1061635. PMID 15767669.
8. ^ "Entrez Gene: TBPL1 TBP-like 1".
9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
10. Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG (Nov 1999). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13720–5. Bibcode:1999PNAS...9613720T. doi:10.1073/pnas.96.24.13720. PMC 24131. PMID 10570139.

Further reading

• Ohbayashi T, Makino Y, Tamura TA (Feb 1999). "Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor". Nucleic Acids Research. 27 (3): 750–5. doi:10.1093/nar/27.3.750. PMC 148243. PMID 9889269.
• Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG (Nov 1999). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13720–5. Bibcode:1999PNAS...9613720T. doi:10.1073/pnas.96.24.13720. PMC 24131. PMID 10570139.
• Martianov I, Brancorsini S, Gansmuller A, Parvinen M, Davidson I, Sassone-Corsi P (Feb 2002). "Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids". Development. 129 (4): 945–55. doi:10.1242/dev.129.4.945. PMID 11861477.
• Kieffer-Kwon P, Martianov I, Davidson I (Oct 2004). "Cell-specific nucleolar localization of TBP-related factor 2". Molecular Biology of the Cell. 15 (10): 4356–68. doi:10.1091/mbc.E04-02-0138. PMC 519132. PMID 15269281.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• TBPL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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