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FOXD4
Identifiers
Aliases	FOXD4, FKHL9, FOXD4A, FREAC-5, FREAC5, forkhead box D4
External IDs	OMIM: 601092; MGI: 1347467; HomoloGene: 83248; GeneCards: FOXD4; OMA:FOXD4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p24.3 Start 116,231 bp End 118,417 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 B|19 19.86 cM Start 24,876,600 bp End 24,878,561 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Cerebellum cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum granulocyte prefrontal cortex putamen stromal cell of endometrium anterior cingulate cortex caudate nucleus Top expressed in granulocyte embryo hypoblast embryonic organizer red nucleus endoderm notochord spermatocyte mesoderm spinal ganglia More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA binding, bending DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II anatomical structure morphogenesis cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2298 14237 Ensembl ENSG00000170122 ENSMUSG00000051490 UniProt Q12950 Q60688 RefSeq (mRNA) NM_207305 NM_008022 RefSeq (protein) NP_997188 NP_032048 Location (UCSC) Chr 9: 0.12 – 0.12 Mb Chr 19: 24.88 – 24.88 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein D4 is a protein that in humans is encoded by the FOXD4 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000170122 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000051490 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P (Dec 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". EMBO J. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.
6. Larsson C, Hellqvist M, Pierrou S, White I, Enerback S, Carlsson P (Feb 1997). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.
7. Freyaldenhoven BS, Fried C, Wielckens K (Sep 2002). "FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines". Gene. 294 (1–2): 131–140. doi:10.1016/S0378-1119(02)00702-3. PMID 12234674.
8. "Entrez Gene: FOXD4 forkhead box D4".

Further reading

• Cederberg A, Betz R, Lagercrantz S, et al. (1997). "Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene". Genomics. 44 (3): 344–6. doi:10.1006/geno.1997.4864. PMID 9325056.
• Fan Y, Newman T, Linardopoulou E, Trask BJ (2003). "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions". Genome Res. 12 (11): 1663–72. doi:10.1101/gr.338402. PMC 187549. PMID 12421752.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Minoretti P, Arra M, Emanuele E, et al. (2007). "A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality". Int. J. Mol. Med. 19 (3): 369–72. doi:10.3892/ijmm.19.3.369. PMID 17273782.

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